Released on = January 15, 2007, 3:45 pm

Press Release Author = Albert Hong

Industry = Biotech

Press Release Summary = SOCS (suppressor of cytokine signaling), as the name
implies, belong to a family of proteins that negatively regulates cytokine signaling
(1).

Press Release Body = The structure of each member of the SOCS family consists of a
central Src homology 2 (SH2) domain and a SOCS box motif of 40 amino acids on the
C-terminus (2,3). The SOCS proteins form part of a classical negative feedback loop
that regulates cytokine signal transduction via a STAT-induced transcriptional
mechanism (4). Transcription of each of the SOCS genes occurs rapidly in vitro and
in vivo in response to cytokines, and once produced, the various members of the SOCS
family appear to inhibit signaling in different ways.

AnaSpec has introduced a suite of SOCS antibodies that have been validated in
western blots using cell or tissue lysates. These polyclonal antibodies, raised in
rabbits and affinity purified, come in a new economical 50 µg format.

Product Size Catalog # Approx MW (kDa) Lysate used in WB
Anti-SOCS-1 50 µg 28132 24 HEK293 (cat# 29520)
Anti-SOCS-2 50 µg 28133 26 Mouse liver (cat# 29509)
Anti-SOCS-3 50 µg 28134 27 MCF-7 (cat# 29519)
Anti-SOCS-4 50 µg 28135 55 Mouse brain (cat# 29507)
Anti-SOCS-5 50 µg 28136 61 A431 (cat# 29514)

For more information, visit www.anaspec.com

AnaSpec, Inc., located in San Jose, CA, is a leading provider of integrated
proteomics solutions to pharmaceutical, biotech, and academic research institutions
throughout the world. With a vision for innovation through synergy, AnaSpec focuses
on three core technologies: peptides, detection reagents, and combinatorial
chemistry.

References:
1. Krebs, DL and DJ. Hilton. J. Cell Sci. 113, 2813 (2000).
2. Starr, R. et al. Nature 387, 917 (1997).
3. Hilton, DJ. et al. Proc. Natl. Acad. Sci USA 95, 114 (1998).
4. Yoshimura, A. Cytokine Growth Factor Rev. 9, 197 (1998).



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